DNA ligases seal 5′-PO4 and three′-OH polynucleotide ends by way of a few nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates https://stevem901wqj5.magicianwiki.com/user